Lower Adherence to Clotting Factor Replacement Therapy in Patients with Haemophilia Associated with More Depressive Symptoms: Two Centers Cross-Sectional Study

Authors

  • Ana Butkovic Faculty of Humanities and Social Sciences, University of Zagreb, Zagreb, Croatia
  • Martina Bago Andrija Stampar Teaching Institute of Public Health, Zagreb, Croatia
  • Irena Preloznik Zupan University Medical Center Ljubljana, Ljubljana, Slovenia; Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
  • Barbara Faganel Kotnik University Medical Center Ljubljana, Ljubljana, Slovenia
  • Ivana Prga Andrija Stampar Teaching Institute of Public Health, Zagreb, Croatia
  • Vesna Bačić Vrca Clinical Hospital Dubrava, Zagreb, Croatia; Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia
  • Silva Zupančić Šalek University Hospital Centre Zagreb, Zagreb, Croatia; Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia

DOI:

https://doi.org/10.31577/sp.2022.01.839

Keywords:

medication adherence , depressive symptoms, patients with haemophilia

Abstract

The aim of this study was to examine the association of depressive symptoms, assessed with a longer measure designed and validated for diagnosing or screening for depression, with medication adherence levels in a combined sample from Croatia and Slovenia. Participants in the study were adult patients with haemophilia receiving prophylaxis or on demand treatment (N = 109). Their age was between 18 and 73 years (M = 43.86, SD = 14.89). Self-reported medication adherence (implementation phase) was measured with VERITAS-Pro and VERITAS-PRN scales, while depressive symptoms were measured with BDI-II. Comparison of adherence scores using t-test indicated that participants using on-demand treatment had worse total adherence score as well as time, dose, plan and communicate subscale scores than participants using prophylaxis. In hierarchical regression analyses depressive symptoms were significant predictor for time subscale and the total score after controlling for sociodemographic and clinical variables.

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Published

2022-03-16

How to Cite

Butkovic, A., Bago, M., Preloznik Zupan, I., Faganel Kotnik, B., Prga, I., Bačić Vrca, V., & Zupančić Šalek, S. (2022). Lower Adherence to Clotting Factor Replacement Therapy in Patients with Haemophilia Associated with More Depressive Symptoms: Two Centers Cross-Sectional Study. Studia Psychologica, 64(1), 64–75. https://doi.org/10.31577/sp.2022.01.839

Issue

Section

Special Issue: Psychological roots of questionable health practices

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